For instance, in recipients of non-adjuvanted influenza vaccine, local or systemic reactogenicity events corresponded with post-vaccination levels of MIF and/or TNF-α, but not of IL-6, IL-8, or IL-1β (61), and CRP increases seen in other clinical vaccine trials were also not clearly associated with reactogenicity (62–64). The gene discussed is CXCL8; the disease is influenza.