Furthermore, a local increase in serotonin levels in the hypothalamus has already been linked to anorexia and cachexia (65–67) and a recent study showed that inflammation induced by peripheral treatment by either IL-6 and/or TNF-α is associated with an impairment in local serotonin turnover in the hypothalamus, a decrease in NPY and AgRP gene expressions, and a decrease in food intake in comparison to control conditions (68). The gene discussed is AGRP; the disease is Anorexia.