POMC and Anorexia: Indeed, they showed through different approaches that the NF-κB pathway in the melanocortin system plays an important role in illness-induced anorexia and body weight loss: both administration of AgRP, an endogenous melanocortin antagonist and the inhibition of the NF-κB pathway specifically in the POMC neurons (IkkβΔPomc mice), significantly blunted the effects of Tat and LPS on food intake and body weight.