For example, Sallinen et al. (43) demonstrated deficient sensorimotor gating (see Cognitive Deficits Associated With MDD and Schizophrenia) in α2C-KO mice, suggesting that α2C-AR antagonism may induce effects likened to psychotomimetic agents such as phencyclidine (PCP). Here, IGKV2D-29 is linked to major depressive disorder.