To this end α2-AR antagonists mianserin and mirtazapine have seen widespread use in the therapy of major depressive disorder (MDD), while almost all atypical antipsychotics display moderate to potent levels of α2-AR antagonism, which has been suggested to underlie the atypical profile of antipsychotics such as clozapine, quetiapine, risperidone, and asenapine (3, 4). Here, ADORA2A is linked to major depressive disorder.