miR-222 is considered an oncogenic gene in most epithelial tumors [20], promoting oncogenic process by targeting PTEN and TIMP3 in NSCLC and hepatocellular carcinoma [21, 22].Up-regulation of miR–222 induces an enhancement of proliferation by down-regulating its target P27Kip1 in ovarian and hepatocellular cancer [23, 24]. Here, CDKN1B is linked to hepatocellular carcinoma.