Given that CIC deficiency induced autoimmunity and that Cic null CD4+ T cells more robustly responded to TCR stimulation than WT cells in vitro (Fig. 3c,d), we assessed thymic negative selection, which is a critical process that removes autoreactive T cells in thymus43, in WT and Cicf/fCd4-Cre mice. This evidence concerns the gene CIC and Autoimmunity.