Given that excessive formation of TFH cells is often observed in patients with autoimmune diseases5 and that autoimmunity in Roquinsan mice is reduced when TFH cell development is suppressed either by removing one allele of Bcl6, by deleting SAP (Sh2d1a), or by dampening IFNγ signalling40, 60, spontaneous induction of the GC response might be a primary cause of the onset of autoimmune-like symptoms in Cic mutant mice. The gene discussed is IFNG; the disease is Autoimmunity.