CD4 and Autoimmunity: The immune cell-specific Cic null mice shared many phenotypes including hyperglobulinemia, T-cell hyperactivation, accumulation of effector/memory cells with TH1 and TH2 phenotypes, systemic autoimmunity and increased proportions of CD4+FOXP3+CD25− T, TFH and GC B cells with the T-cell-specific Cic null mice, demonstrating that T-cell-intrinsic functions of CIC are crucial for maintenance of T-cell homeostasis and suppression of spontaneous induction of the GC response and autoimmunity.