Interestingly, GRIA2 Q/R site appeared highly edited in almost all brain locations (average editing levels from 0.82 to 0.99), while editing levels of spinal cord samples (n = 15, average editing levels of 0.66) were quite similar to our values for both ALS (average editing levels of 0.62) and control (average editing levels of 0.66) groups, meaning that RNA editing levels at GRIA2 Q/R site are not always edited at nearly 100% in spinal cord (Fig. 7A and Supplementary Table 12). Here, GRIA2 is linked to amyotrophic lateral sclerosis.