HECW1 and amyotrophic lateral sclerosis: From the list of differentially expressed genes, we selected 16 candidates including genes known to be deregulated in ALS such as INA, HECW1 and SLC1A2 (representing a sort of internal control) and genes not yet described as altered in ALS but associated to significantly disrupted pathways such as the cholesterol biosynthesis, the complement system or the synaptic transmission (Table 5).