More and more studies have shown that patient with a pathogenic FBN1 mutation is at risk for developing Marfan-like syndromes such as severe cardiovascular, skeletal, and ophthalmologic complications5, 6, 20 and et al. Faivre L et al. 40 pointed out that exons 24–32 represented a hotspot for neonatal MFS and severe forms of MFS. The gene discussed is FBN1; the disease is Marfan syndrome.