Case TAAD034 with AD had two novel heterozygous variants: c.8069T > G in FBN1 and c.1523G > A in MYH11.Although no family history was confirmed in this patient, c.1523G > A in MYH11was predicted to be pathogenic by two programs (SIFT and PolyPhen) while c.8069T > G in FBN1 showed a nonpathogenic result. This evidence concerns the gene MYH11 and Alzheimer disease.