AHI1 and Other metabolic disease: On the other hand, the chromosome 6q region harbors the AHI1 (human Abelson helper integration site-1) gene which has been shown to be associated with neurological, hematologic, and metabolic diseases.20, 21 Variation in MHC genes could be associated with SZ, in part through impaired immune responses, increase related to predisposition to viral infection(s),22, 23 neuroinflammation or even altered synaptic plasticity.24 Cognitive impairment, one of the deficits, central to SZ etiology25 has been observed consistently.