AHI1 and Cognitive impairment: Variation in the genes governing these functions might render the person susceptible to pathogens, which may in turn disrupt the internal homeostasis and alter synaptic plasticity, thus leading to cognitive deficits.50, 55 Alternately, since AHI1 is known to have a site for provirus integration and is involved in ciliary machinery that allows differential protein diffusion, and NFKBIL1 is involved in immune response, these genes may be interacting to maintain internal homeostasis by restricting unsolicited pathogen entry.