GUK1 and breast neoplasm: Another example is driver module 18, which includes the genes BAIAP2, EEF1A2, GUK1, PPP1R3B, TEX2, and TRPS1. Except for gene PPP1R3B, which was mainly mutated or deleted, the other five genes were mainly amplified among TCGA breast tumors with abnormal expression of genes in gene transcriptomic module 18 (refer to Fig. 3B).