NRXN1 and schizophrenia: These findings in the Japanese population have, in part, been replicated and extended in the most recent and largest European (21,094 cases and 20,227 controls) analysis of CNVs in schizophrenia.32 In this study, investigators identified a 11% greater global CNV burden in cases compared to controls (p = 5.7 × 10−15) among which eight loci, 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2, and 22q11.2, obtained genome-wide significance.