TRIM15 and schizophrenia: As reported above, classical HLA typing has been undertaken in the context of clozapine-induced agranulocytosis in the Japanese population20 and others have identified excessive homozygosity in the MHC region of Ashkenazi Jews with schizophrenia, specially in a segment encompassed by TRIM10, TRIM15, and TRIM40. 34 However, the mechanism by which these genes and more broadly the MHC region confer risk for schizophrenia remains largely undetermined.