ELAVL2 and schizophrenia: These selected SNPs were then examined in 506 cases and 506 age-matched and sex-matched controls from which the top SNP was rs10491817 in the ELAVL2 gene (p = 8.7 × 10−4), a neuronal-specific RNA-binding protein involved in mRNA splicing and transcription regulation.13 The gene is known to bind to 3′ untranslated repeats and promote RNA degeneration.14, 15 They then conducted dense genotyping of the ELAVL2 gene in 293 Chinese pedigrees (n = 1163) that showed a nominal association (lowest p = 0.026) in intron 1 with schizophrenia.