Our laboratory has focused on the role of baicalein in PD treatment for several decades, and prior data indicated that baicalein exerted a neuroprotective action against MPTP-induced damage in C57BL/6 mice, attenuated muscle tremor and increased the number of tyrosine hydroxylase (TH) neurons through its anti-oxidative action in 6-hydroxydopamine (OHDA)-lesioned rats14–17. The gene discussed is TH; the disease is Parkinson disease.