CACNA2D3 and neoplasm: The most significant signal associated with CAC was lower expression of CACNA2D3 (calcium channel, voltage-dependent, alpha 2/delta subunit 3; P = 2.08 × 10−8, FDR = 3.19 × 10−4; with carotid plaque: P = 6.71 × 10−3, FDR = 0.40) a tumor suppressor gene that can induce mitochondrial-mediated apoptosis30.