As shown in Fig. 3b, it overlaps a DNase hypersensitive hotspot (BLUEPRINT monocyte data36, 37), a predicted strong enhancer (using both monocyte and B-cell line histone mark data from the BLUEPRINT36, 37 and ENCODE38 projects, respectively), and a transcription factor-binding site occupied by EP300 (in a neuroblastoma cell line). Here, EP300 is linked to neuroblastoma.