ARID5B expression was positively associated with many CVD risk factors (FDR < 0.05 with adjustment for demographic variables), such as age, (P = 2.06 × 10−13), BMI (P = 1.67 × 10−8), T2DM (P = 3.43 × 10−5), and inflammatory stress (measured by plasma interleukin-6 levels (IL-6; P = 1.36 × 10−10), and inversely associated with HDL-C levels (P = 6.86 × 10−6). Here, ARID5B is linked to type 2 diabetes mellitus.