MSMO1 and atherosclerosis: Out of the five atherosclerosis-associated eMS, four had methylation correlated with mRNA expression profiles that were nominally (P < 0.05) associated with atherosclerosis, including expression of SC4MOL. The CpG most significantly associated with CAC (cg05119988, located in the 5′-untranslated region of SC4MOL) significantly correlated (r = −0.17, P = 1.2 × 10−10, FDR = 7.3 × 10−8) with mRNA expression of SC4MOL, a member of the identified CMNT, which was nominally associated with both carotid plaque and CAC.