Expression of two genes, ARID5B and PDLIM7 (PDZ and LIM domain protein 7), were positively associated with both measures of atherosclerosis (FDR ≤ 0.05); ARID5B was most significantly associated with carotid plaque score (P = 6.30 × 10−8, FDR = 1.08 × 10−3; with CAC: P = 2.47 × 10−5, FDR = 0.03). This evidence concerns the gene ARID5B and atherosclerosis.