To further demonstrate the clinical relevance of ARID5B, we associated the tertiles of ARID5B mRNA expression and ARID5B cg25953130 methylation with presence of carotid plaque (defined as carotid plaque score greater than zero, N = 816 cases), presence of CAC (defined as CAC > 0, N = 844 cases), and prevalent CVD (history of a coronary heart event or stroke, N = 64 cases). The gene discussed is ARID5B; the disease is Stroke.