In the high-content screen, only two out of the total 92 (2%) mbt-SPRs identified (CG11843 and CG4975) are significantly upregulated in mbt tumours, the expression levels of 84 mbt-SPRs (82%) are not significantly different in mbt with respect to wild-type brains, and six mbt-SPRs (6%; Pbgs, homer, lig3, CG1024, CG4552 and CG12182) are actually downregulated in mbt tumours [12]. This evidence concerns the gene ALAD and neoplasm.