Although initially discrepant results regarding the effects of a loss of TREM2 function on amyloid plaque pathology were reported (Jay et al, 2015; Wang et al, 2015), TREM2 loss of function may lead to the accumulation of fuzzy amyloid plaques suggesting a lack of phagocytic clearance of the plaque halo or reduced prevention of amyloid plaque growth (Wang et al, 2016; Yuan et al, 2016). This evidence concerns the gene TREM2 and amyloidosis.