In addition, synaptic plasticity involving GluA2 internalization has been suggested to play a role in neurological disorders, such as brain ischemia, traumatic brain injury, and Alzheimer’s disease (Hsieh et al., 2006; Bell et al., 2009; Dixon et al., 2009; Chen et al., 2014). The gene discussed is GRIA2; the disease is early-onset autosomal dominant Alzheimer disease.