Sixteen B-lineage acute lymphoblastic leukemia (B-ALL) had ten or more neoepitopes, including five with an ETV6-RUNX1 translocation (ETV), five hyperdiploid B-ALLs, three with intrachromosomal amplification of chromosome 21(iAMP21), one Ph-like, one with IGH-DUX4 translocation and one hypodiploid B-ALL. The gene discussed is DUX4; the disease is acute lymphoblastic leukemia.