HLA-A and central nervous system cancer: The K27M mutations of these two histone H3 genes generated a high affinity neoepitope, ATKAARMSA (4.02 nM), which was predicted to bind the HLA-A*30:01 allele in three high-grade glioma patients, SJHGG008, SJHGG077, and SJHGG004 (Additional file 4).