Among all the ESCC lncRNA expression profile studies, lncRNA CASC9 has been also reported to be extremely up-regulated in ESCC tissues by Cao’s and Xu’s teams using another microarray platform and RNA sequencing technology [12, 13], which confirms the accuracy of our microarray result and implies the crucial role of CASC9 in the development of ESCC as well. Here, CASC9 is linked to esophageal squamous cell carcinoma.