CEACAM5 and neoplasm: The diagnostic performance of a serial of tumor markers for MPE, such as carcino-embryonic antigen, carbohydrate antigen 19–9, carbohydrate antigen 15–3, has been summarized by two meta-analysis, and studies suggested that one tumor marker alone doesn’t have not enough sensitivity to diagnose MPE, the combination of two or more tumor markers may increase the sensitivity and play more role in MPE diagnosis and management [33, 34].