ENO2 and Pleural effusion: The levels of NSE in both serum and pleural effusion were significantly increased in patients with MPE than in patients with BPE (serum 19.51 ± 16.54 vs. 13.77 ± 13.33 ng/ml, p = 0.004; pleural effusion 18.53 ± 27.30 vs. 6.41 ± 6.95 ng/ml, p < 0.001) (Table 1).