PRSS3 and lung cancer: The other mutations, absent in the ExAc database but present in the COSMIC database (in different tumour types), might be relevant, such as p.W38fs* in HLA-DRB1, p.Q30fs* in AQP7, p.C135R in TP53, p.Q220* in HLA-DRB5, p.G8V in PRSS3, p.S1155R in USH2A and p.V521I in KCNT2. The p.K41T mutation in HLA-DRB1, p.IT255T and p.Q136E in TP53 and p.P2811S in USH2A are also described in human lung cancer samples.