Those 18 SNPs are located at or near the following genes that have been reported to be related to RA: C6orf10 [40], NOTCH4 [41], HLA-DQB2 [42], HLA-DMB [43], HLA-DMA [43], and BRD2 [44]. This evidence concerns the gene HLA-DQB2 and rheumatoid arthritis.