We show that ZIP13 is a crucial regulator of beige adipocyte differentiation, and negatively regulates C/EBP-β protein levels, illustrating the physiological relevance of the ZIP13-C/EBP-β axis in beige adipocyte biogenesis and thermogenesis, and its therapeutic potential in obesity treatment. This evidence concerns the gene SLC39A13 and obesity due to melanocortin 4 receptor deficiency.