KLF11 and Zinc deficiency: Intriguingly, zinc deficiency significantly reduces the DNA-binding activity of PPARs [22], suggesting that some zinc-containing proteins that participate in brown/beige adipocyte differentiation and function (e.g., PRDM16, Kruppel-like factor 11 (KLF11), and Zfp516) might be dysregulated by changes in zinc homeostasis.