Endothelial dysfunction in NAFLD can be caused by subclinical inflammation, oxidative stress, procoagulation process with elevate LDL-C and plasminogen activator inhibitor 1 levels, remodeling of elastic properties in the arterial wall, or decreased plasma adiponectin concentrations [23, 24, 26–32]. The gene discussed is SERPINE1; the disease is endothelial dysfunction.