miRNAs regulate multiple functions in T cells such as TCR signaling, proliferation, differentiation, cytokine secretion and apoptosis[9] E.g. miR-146a upregulation upon TCR stimulation increases the overall TCR signaling and, thereby, enhances cell activation and cell expansion[10] miR-155 targets SOCS1, Ship1 and many other mRNAs that participate in type 1 interferon (IFN) signaling and promotes CD8+ T cell proliferation and survival[11, 12] miR-17-92 targets the tumor suppressors Pten, ID2, ID3 and the anti-apoptotic bcl-2 and enhances the cell cycle progression of T cells[13]. The gene discussed is PTEN; the disease is neoplasm.