GRIN2B and Parkinson disease: In order to evaluate the effect of the A2A/NR2B combination in a model which more closely resembles the clinical situation, the current study evaluated the antiparkinsonian effects of the combined administration of Tozadenant and Radiprodil, given in the absence of L-Dopa, in the 1-methyl-4-phenyl-1, 2, 3, 6,-tetrahydropyridine (MPTP)-treated marmoset model of PD.