Despite the diversity in the clinical clade, we found that 3-carboxymuconate cyclase (Accession number KP233225; gp60 in S. brasiliensis and gp70 in S. schenckii) is the major antigenic target in the early IgG response of murine, feline [34], and human sporotrichosis [39] whereby, after infection, more and more gp60-70-specific antibodies can be found [63]. Here, EMB is linked to sporotrichosis.