MAPK8 and neoplasm: In these examples, viable scrib−/−RasV12 mosaic animals were recovered when essential steps in tumor development such as oncogenic JNK signaling or the cell cycle were inhibited in scrib−/−RasV12 clones (Brumby and Richardson, 2003; Külshammer et al., 2015; Külshammer and Uhlirova, 2013).