Interestingly, RasV12 inhibits the apoptotic activity of JNK and converts the tumor-suppressor function of Eiger and JNK in scrib−/− cells into a tumor-promoting one in scrib−/−RasV12 cells (Enomoto et al., 2015; Cordero et al., 2010; Uhlirova et al., 2005; Igaki et al., 2006; Uhlirova and Bohmann, 2006). This evidence concerns the gene MAPK8 and neoplasm.