MAPK8 and neoplasm: This tumor-suppressing function of caspases has been reported in mammalian systems (Asselin-Labat et al., 2011; Ho et al., 2009) and in Drosophila, where, for example, scrib mutant cells undergo caspase-dependent apoptosis in a JNK- and Eiger-dependent manner (Brumby and Richardson, 2003; Igaki et al., 2006; Igaki et al., 2009; Uhlirova et al., 2005).