Furthermore, in Drosophila it was previously shown that oncogenic Ras switches the tumor-suppressing function of JNK and Eiger in scrib−/− mutant cells to a tumor-promoting one in scrib−/−RasV12 cells (Igaki et al., 2006; Cordero et al., 2010; Uhlirova et al., 2005; Enomoto et al., 2015). Here, MAPK8 is linked to neoplasm.