DDIT3 and metabolic dysfunction-associated steatotic liver disease: Considering that apoptosis is a detrimental factor in NAFLD,6 it is noteworthy that CHOP, also known as growth arrest‐ and DNA damage‐inducible gene 153, drives ER stress mediated apoptosis.42 Despite elevated CHOP expression, unchanged apoptosis or cell survival markers and caspase signalling further support the concept that UDCA may be beneficial via changing the apoptotic threshold and protecting hepatocytes against more pronounced cell death.