Xiao et al. (2004) demonstrated that DATS-induced apoptosis in prostate cancer (PC-3) cells was associated with activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and c-jun N-terminal kinase 1 (JNK1) and/or JNK2. The gene discussed is MAPK3; the disease is Familial prostate cancer.