Indeed, diffuse intrinsic pontine gliomas, which often harbor H3 K27M mutation and SOX10 upregulation, also frequently show higher expression of PDGFRA and a specific PDGFRA-related gene expression signature, indicating that the PDGFRA-related gene expression signature is shared by “K27” gliomas and DCGs categorized in the “RTK I (PDGFRA)” methylation group [33, 34]. This evidence concerns the gene SOX10 and central nervous system cancer.