Ependymoma, a different histological type of glioma, was also demonstrated to have a different molecular profile according to the anatomical region of the original tumor; oncogenic fusions involving RELA or YAP1 were generally seen in supratentorial ependymomas, whereas posterior fossa ependymomas had an extremely low number of mutations, and their pediatric subset showed a typical DNA methylation pattern [26, 31, 32]. This evidence concerns the gene RELA and ependymoma.