In that regard, we think that it is especially interesting that DCGs and K27M midline gliomas had a similar methylation pattern in the promoters of key developmental transcription factors such as SOX10, FOXG1, OLIG1, and OLIG2, suggesting a particular commonality in their cell of origin or tumor developmental process that appears to be distinct from other cerebral gliomas. Here, FOXG1 is linked to central nervous system cancer.