Notably, our analysis revealed not only that the status of OLIG1+, OLIG2+, and FOXG1− was shared between DCGs and K27M midline gliomas, but also that SOX10 promoter hypomethylation and consequent gene overexpression was commonly found among these tumors, whereas SOX10 expression is repressed by promoter hypermethylation in most other cerebral high-grade gliomas. The gene discussed is OLIG1; the disease is glioma.