TNF and rheumatoid arthritis: Recognizing this trend, the 2015 American College of Rheumatology (ACR) Guideline for the Treatment of Rheumatoid Arthritis [3] now includes downward tapering of disease-modifying antirheumatic drug (DMARD) therapy, anti-TNF therapy, non-TNF biologics, or tofacitinib in patients with established RA who have achieved remission.