MPO and metabolic dysfunction-associated steatohepatitis: Neutrophil myeloperoxidase enzyme-induced oxidative stress promotes the formation of oxidized phosphatidylcholine and progression of hepatic steatosis in patients with NASH [122], but a deficiency of myeloperoxidase reduces neutrophil infiltration, fat accumulation, and fibrotic change in the livers of low-density lipoprotein-deficient mice fed a high-fat diet [123].