Moreover, in order to further categorize intermediate risk individuals, more novel risk factors such as Lp-PLA2, LDL-P, fibrinogen, Lp-a, small dense low density lipoprotein (LDL), plasminogen activator inhibitor (PAI-1), IL-6, CRP, coronary artery calcification (CAC) and carotide intima-media thickness can be used [25]. The gene discussed is CRP; the disease is coronary artery calcification.