However, a recent study demonstrated enhanced ER-mitochondria tethering in primary fibroblasts from Parkin knockout mice and PD patients with PARK2 gene mutations as well as in neurons derived from induced pluripotent stem cells of a patient with PARK2 gene mutations along with ER-to-mitochondria calcium transfers likely due to increased Mfn2 in MAMs [76]. Here, PRKN is linked to Parkinson disease.