ALS/FTD-associated TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS) could also disrupt the MERC and perturb mitochondrial calcium uptake from ER through activation of glycogen synthase kinase 3β (GSK3β) which in turn perturbs VAPB-PTPIP51 interaction [28]. Here, FUS is linked to amyotrophic lateral sclerosis.