NOS2 and bacterial infectious disease: Furthermore, this pathogen can inhibit host innate immune response by interfering the inducible nitric oxide synthase (iNOS) expression in mouse macrophage cell line (RAW 264.7) [8], and can induce the multinucleated giant cells (MNGCs) formation for distributing bacterial infection to the adjacent cells before undergoing apoptotic cell death [9, 10].