Formononetin, ononin, calycosin and calycosin-7-O-β-d-glucoside, the predominant bioactive components found within AR, possessed hematopoietic functions by stimulating protein expressions of hypoxia-inducible factor-1α (HIF-1α) and erythropoietin (EPO) in cultures [10]; the combination of these 4 flavonoids increased the hematological parameters in anemia rat models [11]. This evidence concerns the gene EPO and anemia (phenotype).