This review aims to elucidate the role of chronic inflammation in colitis-associated CRC with a review regarding the contribution of inflammatory signaling pathways, including nuclear factor kappa B (NF-κB), IL-6/STAT3, cyclooxygenase-2 (COX-2)/PGE2, and IL-23/Th17. This evidence concerns the gene NFKB1 and colorectal carcinoma.