STIP1 and esophageal squamous cell carcinoma: For all ESCC patients in the training cohort, autoantibodies against STIP1 had an AUC of 0.682 (95% CI: 0.619–0.746) to distinguish individuals with ESCC from normal controls with a sensitivity/specificity of 41.9% (95% CI: 33.9%–50.3%)/90.1% (95% CI: 82.6%–94.7%) (Figure 2, Table 3).