PECAM1 and neoplasm: Given the reported significant relevance of tumor endothelial cells related angiogenesis to tumor metastasis1, 9, 39, 40, as well as high metastatic potential of CTMs in carcinoma patients2, 44, extensive co-investigation of aneuploid CTCs and CD31+ tumor CECs, will help further illustrate how those diverse subtypes of aneuploid malignant cells have a cross-talk and functional interplay with tumor angiogenesis, progression and metastasis, respectively.