APP and amyloidosis: Amyloid plaques and CAA were shown to be reduced in APP/PS1 (amyloid plaque model) and TgSwDI (CAA Tg model) model mice, respectively, while in 3xTg mice (amyloid plaque and tau pathology model) p13Bri immunization led to reductions of both tau and Aβ pathology14, 15, 21, 22, 31.