MAPT and Alzheimer disease: The most common NDD is Alzheimer’ disease (AD) characterized pathologically by its signature lesions of amyloid β (Aβ) deposits in the form of extracellular plaques and vascular amyloid; as well as, tau protein aggregates in the form of intracellular paired helical filaments (PHF) in neurofibrillary tangles (NFT)4, 5.