The previously published p13Bri vaccine inoculated with Aluminum Hydroxide (Alum) as an adjuvant produced a mild polyclonal response to pathologic oligomeric forms present in three mouse models of AD; i.e.,Tg APP/PS1 (with mainly amyloid plaques), Tg SwDI (with extensive vascular amyloid) and 3xTg APP/PS1 P301L (with combined Aβ and tau pathologies)14, 21, 22. The gene discussed is APP; the disease is Alzheimer disease.