Inoculation of p13Bri with Alum as an adjuvant in these three AD Tg models produced a systemic polyclonal response to pathologic/oligomeric forms of both Aβ and tau, as well as demonstrating cross-specificity to AD, prion disease, and LBD human brain tissue (Fig. 2 and results not shown). Here, MAPT is linked to Alzheimer disease.