Furthermore, the associated mechanisms of Neohesperidin (an antioxidant activity in scavenging the DPPH radical) and GKT137831 (dual Nox1/Nox4 inhibitor) could be excluded, however, how S17 induces lethal ROS generation in gastric cancer cells MGC803 needs to be further investigated. The gene discussed is NOX1; the disease is gastric cancer.