Here we report for the first time that the podocyte GR plays a protective role in the glomerular filtration barrier in vivo in the setting of acute systemic injury (LPS) and in crescentic glomerulonephritis (NTS), as evidenced by worsening proteinuria and podocyte injury in pGR KO mice. This evidence concerns the gene NR3C1 and crescentic glomerulonephritis.