EIF2B is essential in all cells of the body for protein synthesis under different stress conditions, and there were five eukaryotic initiation factor 2B subunits encoded EIF2B namely EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, which was known to cause white matter abnormalities42, but no studies have been reported that EIF2B might be related with cancers. This evidence concerns the gene EIF2B5 and cancer.