COL23A1 and cancer: Exogenously expressed recombinant COL23A1 competed with corneal epithelial cell surface COL23A1 for binding to collagen IV and Matrigel24, and COL23A1 directly interacted with integrin α2β1 and sufficiently induced integrin α2β1-dependent attachment and spreading of keratinocytes25, corroborating the results of Spivey et al., who reported that COL23A1 played a role in cancer cell adhesion, anchorage-independent growth, and metastasis17.