Univariate Cox proportion hazard ratio (HR) analysis showed that tumor size (HR: 3.437, P = 0.001), ECOG performance (HR: 6.259, P = 0.000), T stage (HR: 6.449, P = 0.000), ISUP grade (HR: 2.944, P = 0.001), necrosis (HR: 4.628, P = 0.002), and COL23A1 expression status (HR: 3.459, P = 0.004) were associated with OS. This evidence concerns the gene COL23A1 and neoplasm.