This network was composed primarily of genes involved in immune-mediated ECM remodeling, and included connections with many intermediate genes that have been strongly linked to myopia in previous targeted studies (e.g. MMP2, TGFB1, TGFB2, FGF2, INS, and IGF2; see Supplementary Table S6). The gene discussed is TGFB2; the disease is myopia.