TNF and legionellosis: For the DEGs-OT, 37 pathways were significantly enriched (Fig. 7B and Table S20), the top 10 pathways were HIF-1α transcription factor network, Toll-Like Receptor (TLR) Pathway, Ribosome biogenesis in eukaryotes, IL6-mediated signaling events, Malaria, Cytokine-cytokine receptor interaction, TNF signaling pathway, Spinal Cord Injury, Leishmaniasis, Legionellosis.