As infection progressed, we detected a robust upregulation of genes encoding cytokines and chemokines (CCL2, CCL3, IL1B, CXCR1, IL1RN) as well as granulocyte associated transcripts (TLRs 1-4, SPI1, S100A8, S100A9, CD177), which correlated with the higher numbers of granulocytes 5 DPI. The gene discussed is SPI1; the disease is infection.