The analyses of twenty glioblastoma tumor tissues showed a positive correlation between Ape1 and Chk2 both at the protein (r = 0.65; p = 0.0015; n = 20) and mRNA (r = 0.61; p = 0.0037; n = 20) levels (Fig. S8A–D). Here, CHEK2 is linked to neoplasm.