PIK3CD and cancer: The use of PI3K isoform specific inhibitors and PI3K gene targeted mice have revealed non-redundant functions of the Class I PI3K isoforms [24] and PI3K isoforms are considered therapeutic targets in different diseases, mainly cancer and inflammation [25 ]; p110δ regulates B- and T-cell functions, mast cells activation and macrophages proliferation and migration [26–28].