TP53 and cancer: Number of reports suggest that TRIM28 may serve as a pro-tumorigenic factor that when highly expressed, may facilitate cancer progression and metastasis by inducing EMT [71, 73, 74], mediating metabolic switch in stressed conditions [104–106] and downregulating the activity of p53 [77, 85, 127], which collectively enable cancer cells to progress through the cell cycle despite number of errors within the genome.