In our studies, we have demonstrated that downregulation of TRIM28 in highly aggressive, undifferentiated cells of triple-negative breast cancer MDA-MB-231 cell line, which is highly enriched in vitro in CSC-like population characterized by CD44+CD24−/low phenotype, led to significant (p < 0.0001) inhibition of tumor growth in vivo upon subcutaneous cell injection into athymic nude mice [25]. This evidence concerns the gene TRIM28 and neoplasm.