ACHE and Dravet syndrome: The AChE activity measurements were normalized to total protein content in the brain tissue and the results supported the finding of DS-induced higher levels of exosomes with a trend in the brain extracellular space of DS patients (DS/2N ratio = 1.29, p = 0.14) (Fig. 1d), and conclusively in 12- (Ts2/2N ratio = 1.26, p = 0.00016) and 24-month-old (Ts2/2N ratio = 1.35, p = 0.00081) Ts2 mice (Fig. 1e).